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Blood begins to pool causing the vein to stretch and become swollen and knotted. When this happens, visible varicose veins appear. Vein disease has a strong genetic link and tends to run in families. Females are more likely to develop varicose veins due to hormones and the stress of pregnancy.… Blood begins to pool causing the vein to stretch and become swollen and knotted. When this happens, visible varicose veins appear. Vein disease has a strong genetic link and tends to run in families. Females are more likely to develop varicose veins due to hormones and the stress of pregnancy. Occupational requirements are also a big risk factor in the development of varicose veins. Read more