Welcome to Holiday Inn Express & Suites Hannibal - Medical Center, your comfortable base for exploring this storied stretch of northeast Missouri. Our Hannibal hotel places you close to the Mark Twain Boyhood Home & Museum, the adventure-filled Mark Twain Cave, and scenic views along the Mississippi River. Whether you're here for a quick getaway or to experience the charm... Read More about Holiday Inn Express & Suites Hannibal - Medical Center by IHG

Located in Hannibal,MO, the Best Western On the River is sure to provide a peaceful and comforting home away from home for any traveler. Each Best Western hotel provides free internet access, giving guests the opportunity to check emails and surf the web, all from the comforts of their room or the business center. With cleanliness and value being our... Read More about Best Western On the River